In our last newsletter instalment, as part of our ongoing overview of auxiliary IVF lab techniques, we looked at intracytoplasmic sperm injection, or ICSI. In this issue, we continue that review with IMSI—intracytoplasmic morphologically selected sperm injection.
Like ICSI, IMSI is a method of sperm selection and may be viewed as a more highly-developed form of ICSI. But, whereas the conventional microscope used in ICSI features a magnification of 400x, that used in IMSI boasts a potential magnification of up to 6600x.
This significant boost in magnifying power allows structures within the head of sperm, known as vacuoles, to be revealed—structures that would otherwise goes unseen. And this is important, because vacuoles have shown themselves to be indicators of nuclear and/or DNA damage. As such, sperm bearing vacuoles are compromised in their capacity for fertilisation, and their use can lead to abnormal embryonic development, failed implantation, and miscarriage.
IMSI helps circumvent these issues by enabling embryologists to reject sperm with larger or more abundant vacuoles and to preferentially-select those with smaller or fewer such structures. This, in turn, helps to ensure successful implantation and sound embryonic development, which bodes well for pregnancy.
IMSI is but one tool in an extensive kit our embryologists utilise to help you get pregnant. Contact us today to learn more.